CHM Faculty

Bryce Reeve, PhD
Director, Center for Health Measurement

Dr. Reeve is a Professor of Population Health Sciences and Pediatrics within the Duke University School of Medicine where he directs the Center for Health Measurement. He is an internationally-recognized psychometrician whose work focuses on the quality of care for patients of all ages with chronic diseases. Dr. Reeve's areas of expertise are in developing patient-reported questionnaires using qualitative and quantitative methodologies and the integration of patient-reported data in research and healthcare delivery to inform decision-making.

From 2000 to 2010, Dr. Reeve served as Program Director of the NIH’s National Cancer Institute where he was integral in developing their Patient-Reported Outcomes Measurement Information System (PROMIS) initiative and oversaw a program of health-related quality of life research. From 2010-2017, he served as Professor of Health Policy and Management at the Gillings School of Public Health at the University of North Carolina at Chapel Hill where he successfully secured NIH and PCORI funding to design and validate PRO measures. Currently, Dr. Reeve is PI on an NIH-funded longitudinal study to validate PROMIS measures in children with sickle cell disease, asthma, nephrotic syndrome and cancer and another for children with cancer, rheumatic disease, or inflammatory bowel disease. Also, he is PI on a NIH-funded study to design and validate a system (i.e., PRO-CTCAE) for children to self-report symptom toxicities experienced while undergoing cancer treatment.   

Kevin Weinfurt, PhD
Co-Director, Center for Health Measurement

Dr. Weinfurt is Professor and Vice Chair for Research in the Department of Population Health Sciences in the Duke University School of Medicine. He is also Professor of Psychiatry and Behavioral Science at Duke University Medical Center and a faculty member of the Duke Clinical Research Institute; Professor of Psychology and Neuroscience; and a Faculty Associate of the Trent Center for the Study of Medical Humanities and Bioethics.

Dr. Weinfurt was a principal investigator in the NIH PROMIS Network, where he led the development of the SexFS to measure male and female sexual function and satisfaction. Currently, he serves as the President of the PROMIS Health Organization and serves on the Board of Directors of the International Society for Quality of Life Research. He is co-chair of the coordinating center for the NIH Health Systems Research Collaboratory and co-chair of NIDDK’s Symptoms of Lower Urinary Tract Dysfunction Research Network, for which he also leads the Self-Reported Measures workgroup. Dr. Weinfurt has served on advisory panels for the FDA and has taught patient-reported outcomes in educational programs at both the FDA and NIH. Dr. Weinfurt also co-directs Duke’s masters-level Clinical Research Training Program and has taught graduate courses in patient-reported outcomes research and multivariate statistics, along with undergraduate courses in introductory psychology, judgment and decision making, and the psychology of medical decision making.

Dr. Weinfurt’s research has been featured on NPR Marketplace, Business Week, ABC News, and US News & World Report. Dr. Weinfurt received his PhD in Psychology at Georgetown University and did graduate work in the history of science and philosophy of mind at Linacre College, Oxford. 

Dr. Theresa Coles
Assistant Professor in Population Health Sciences

Dr. Coles is an Assistant Professor in Population Health Sciences. She specializes in the development and psychometric evaluation (reliability, validity, responsiveness, and responder thresholds) of patient-reported outcome measures and other clinical outcomes assessments. Her research interests include evaluating COA measures in clinical practice, improving the interpretability of COAs (e.g., responder thresholds, minimal important change), and facilitating patient-provider communication using patient-reported outcome measures.

Dr. Coles received her PhD in Health Policy and Management (decision sciences and outcomes research) from the University of North Carolina at Chapel Hill in 2017. Prior to joining the Duke faculty in 2018, Dr. Coles worked in the Patient-Centered Outcomes Assessment group at RTI Health Solutions for almost 10 years, where she developed and evaluated COA measures for use in clinical trials and clinical practice.

Associate Professor in Population Health Sciences

Dr. Corneli is an Associate Professor in the Departments of Population Health Sciences and Medicine. She is also a faculty associate of the Trent Center for Bioethics, Humanities, and History of Medicine; a faculty associate of the Duke Initiative for Science & Society; a faculty member of the Duke Clinical Research Institute; and a faculty affiliate at the Duke Global Health Institute. Dr. Corneli serves as the Director of the QualCore and The BASE Lab in the Department of Population Health Sciences, and as the Lead Social Scientist for the Clinical Trials Transformation Initiative.

A social scientist by training, Dr. Corneli has over two decades of experience conducting qualitative, formative, and mixed-method studies in multiple countries worldwide, primarily in biomedical HIV prevention and bioethics. A significant portion of her research portfolio has focused on engaging patients/participants and other key stakeholders in qualitative research to inform clinical studies; socio-behavioral interventions, programs, and policies; and material and scale/questionnaire development. Her HIV-related research focuses on identifying evidence-based strategies for linking populations who could benefit from pre-exposure prophylaxis (PrEP) to PrEP care, for supporting PrEP adherence to achieve protective levels, and for keeping clients engaged in PrEP care for as long as their HIV risk persists. Her bioethics research focuses primarily on informed consent and functioning of ethics review boards.

Dr. Corneli received her PhD in Health Behavior from UNC Chapel Hill, with a minor in Anthropology, and her MPH in International Health from Emory University.

Juan Marcos Gonzalez, PhD
Assistant Professor in Population Health Sciences

Dr. Gonzalez is an Assistant Professor in the Department of Population Health Sciences. He is an expert in the design of stated-preference survey instruments and the use of advanced statistical tools to analyze stated-preference data. His research has focused on the transparency in benefit-risk evaluations of medical interventions, and the elicitation of health preferences from multiple stakeholders to support shared decision making.

Dr. Gonzalez co-led the first FDA-sponsored preference study which was highlighted in the FDA’s recent precedent-setting guidance for submitting patient-preference evidence to inform regulatory benefit-risk evaluations of new medical devices. More recently, he collaborated with the Medical Devices Innovation Consortium (MDIC) to prepare the first catalog of preference-elicitation methods (part of the Patient-Centered Benefit-Risk Assessment Framework) suitable for benefit-risk assessments of medical devices. As a core group member of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Conjoint Analysis Task Force, Dr. Gonzalez helped draft good-practice recommendations for statistical analysis, interpretation, and reporting of health preference data. Currently, he is working with the Center for Devices and Radiological Health at FDA to support the development of the Center’s capabilities for the review of stated-preference data in regulatory decisions.

F. Reed Johnson, PhD
Professor in Population Health Sciences

Dr. Johnson, has more than 40 years of academic and research experience in health and environmental economics. He led the first FDA­ sponsored study that measured a patients’ willingness to accept benefit-risk tradeoffs for new health technologies which concluded in FDA guidance on submitting patient-preference data to support regulatory reviews of medical devices. He also designed and analyzed numerous surveys that measure preferences of health risk reductions, improved environmental quality, and the value of health outcomes. Currently Dr. Johnson’s research involves quantifying the patients’ willingness to accept side ­effect risks in return for therapeutic benefits and estimating the general time equivalences among health states.

Dr. Johnson is a Professor in the Department of Population Health Sciences who has published in over 140 books and peer-reviewed journals including the Review of Economics and Statistics, Journal of Health Economics, Medical Decision Making, Health Economics, Value in Health, and the Journal of Policy Analysis and Management

Dr. Heather King
Assistant Professor in Population Health Sciences

Dr. King is an Assistant Professor in the Department of Population Health Sciences and a health services researcher at the Center for Health Services Research in Primary Care at the Durham Veterans Affairs Medical Center (VAMC, HSR&D). She received her PhD in Human Development and Family Studies from Pennsylvania State University where her areas of concentration were developmental research methodology and adult development. Dr. King's research focuses on the relationships between particular psychological/psychosocial variables and health behaviors as well as various indicators of physical health and chronic disease management and prevention. Her interests include implementation science, health services research and health measurement. She also has a strong interest in health and health-related processes within couples and families.

Sheng Lou PhD
Associate Professor in Biostatistics

Dr. Luo is an Associate Professor of Biostatistics at Duke University. He received his Ph.D. in Biostatistics from The Johns Hopkins University and is a leading biostatistician specializing in statistical methods of the design and analysis of clinical trials and observational studies, and latent variable modeling. He has 76 peer-reviewed articles on a variety of statistical topics and diseases and is PI on an ongoing NIH/NINDS grant entitled “Statistical methods for clinical trials with multivariate longitudinal outcomes,” which deals with statistical methodology development for complex longitudinal data in clinical trials. Previously, he was PI on an NIH/NINDS grant “Parkinson’s disease clinical trial: Statistical center,” which provides design and analysis to Phase II and III trials in the NET-PD network and multiple projects regarding Parkinson’s disease and Huntington’s disease rating scale development, validation, and translation funded by the Movement Disorders Society and CHDI Foundation. Dr. Lou serves on multiple national committees, NIH study sections, and editorial boards.

Wei Pan, PhD
Associate Professor in School of Nursing

Dr. Pan is an Associate Professor of Methods and Analytics in the School of Nursing. He received his PhD in Measurement and Quantitative Methods from Michigan State University in 2001 and his MS in statistics from Fuzhou University, China, in 1989. Dr. Pan’s research interests focus on propensity score methods, latent variable modeling, meta-analysis, psychometrics, and their applications in the social, behavioral, and health sciences. Over the years, he has been involved in research projects funded by federal agencies, such as NIH, NSF, and the U.S. Department of Education. In addition to his many methodological publications, he has published numerous collaborative research studies on substantive topics including symptom clusters in children undergoing leukemia treatment. Dr. Pan is the Chair-Elect of the Applied Public Health Statistics Section of the American Public Health Association.

Shelby Reed, PhD
Professor in Population Health Sciences

Dr. Reed is a Professor in the Department of Population Health Sciences. She has 20 years of experience leading multidisciplinary health outcomes research studies that focus on economic and health policy evaluations. Dr. Reed has extensive expertise in designing and conducting trial- and model-based cost-effectiveness analyses of diagnostics, drugs and patient-centered interventions. And in the last several years, her research has increasingly focused on stated-preference studies to evaluate benefit-risk tradeoffs, patient-centered value, and their application in clinical decision making. 

Dr. Reed earned her pharmacy and doctoral degrees from the University of Maryland and completed her training in the pharmaceutical outcomes research and policy [rogram at the University of Washington. She serves on editorial advisory boards for Value in Health and Health Services Research and is currently serving as president of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR).

Assistant Professor in Population Health Sciences

Dr. Zigler is an Assistant Professor in the Department of Population Health Sciences. A psychometrician and statistician by training, she uses rigorous, patient-centered methods to develop and evaluate clinical outcome measures. Specifically, her primary interest is in designing tools for children with rare diseases so that their voices and the voices of their families can be prioritized in research.

Dr. Zigler led the team that developed the Localized Scleroderma Quality of Life Instrument (LoSQI), the first patient-reported outcome (PRO) developed specifically with and for children with localized scleroderma/morphea. Currently, she is collaborating with multidisciplinary teams to adapt the measure for adults and perform cross-cultural validation/translation of the measure into a number of languages. Dr. Zigler was also part of the team that developed the Observer-Reported Communication Ability (ORCA) measure through a partnership with the Foundation for Angelman Syndrome Therapeutics (FAST). The ORCA measure was designed for use in clinical trials to capture caregiver perceptions of communication ability for individuals with Angelman syndrome, a rare neurodevelopmental disorder. Dr. Zigler is currently working on methods to scale up the ORCA measurement model and gather sufficient validity evidence for its use in other neurodevelopmental disorders with similar communication impacts. She also is a co-investigator on the Clinical Outcome Assessments for Acute Pain Therapeutics in Infants and Young Children (COA-APTIC) study, funded by the U.S. Food and Drug Administration.

Dr. Zigler received her PhD in Research Methodology from the University of Pittsburgh and her MSEd in counseling psychology from the University of Miami. She has been involved in research for almost 15 years and has published applied work in rheumatology, pediatrics, human engineering, veterans’ affairs, and rehabilitation science. Her current research interests include using mixed methods to explore meaningful changes in PRO scores, small sample size statistical methods, and anchoring vignettes.